RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-33a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; cell counting kit-8 analysis
Target
CFB
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-33a deficiency inhibits proliferation and fibrosis through inactivation of TGF-beta/Smad pathway in human cardiac fibroblasts
Year
2017
Function
The upregulated phosphorylations were further improved by miR-33 mimic (p <0.05) While reversed by miR-33a inhibitor (p <0.05 Or p < 0.001). miR-33a deficiency inhibits proliferation and fibrosis of CFBS while promotes cardiac fibroblast (CF) apoptosis by inactivation of TGF-beta/smad pathway.